Ontology highlight
ABSTRACT:
SUBMITTER: Zearfoss NR
PROVIDER: S-EPMC3017110 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Zearfoss N Ruth NR Clingman Carina C CC Farley Brian M BM McCoig Lisa M LM Ryder Sean P SP
PLoS genetics 20110106 1
In mice, Quaking (Qk) is required for myelin formation; in humans, it has been associated with psychiatric disease. QK regulates the stability, subcellular localization, and alternative splicing of several myelin-related transcripts, yet little is known about how QK governs these activities. Here, we show that QK enhances Hnrnpa1 mRNA stability by binding a conserved 3' UTR sequence with high affinity and specificity. A single nucleotide mutation in the binding site eliminates QK-dependent regul ...[more]