Ontology highlight
ABSTRACT:
SUBMITTER: Gu TL
PROVIDER: S-EPMC3017127 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Gu Ting-Lei TL Deng Xiaxing X Huang Feizhou F Tucker Meghan M Crosby Katherine K Rimkunas Victoria V Wang Yi Y Deng Gang G Zhu Lei L Tan Zhiping Z Hu Yerong Y Wu Chunlin C Nardone Julie J MacNeill Joan J Ren Jianmin J Reeves Cynthia C Innocenti Gregory G Norris Brett B Yuan Jin J Yu Jian J Haack Herbert H Shen Baiyong B Peng Chenghong C Li Hongwei H Zhou Xinmin X Liu Xunyang X Rush John J Comb Michael J MJ
PloS one 20110106 1
Cholangiocarcinoma, also known as bile duct cancer, is the second most common primary hepatic carcinoma with a median survival of less than 2 years. The molecular mechanisms underlying the development of this disease are not clear. To survey activated tyrosine kinases signaling in cholangiocarcinoma, we employed immunoaffinity profiling coupled to mass spectrometry and identified DDR1, EPHA2, EGFR, and ROS tyrosine kinases, along with over 1,000 tyrosine phosphorylation sites from about 750 diff ...[more]