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Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.

ABSTRACT: CO(2) is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO(2) avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO(2) specifically activates the BAG neurons and that the CO(2)-sensing function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion channels and the receptor-type guanylate cyclase GCY-9. Our results delineate a molecular pathway for CO(2) sensing and suggest that activation of a receptor-type guanylate cyclase is an evolutionarily conserved mechanism by which animals detect environmental CO(2).

SUBMITTER: Hallem EA

PROVIDER: S-EPMC3017194 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.

Hallem Elissa A EA Spencer W Clay WC McWhirter Rebecca D RD Zeller Georg G Henz Stefan R SR Rätsch Gunnar G Miller David M DM Horvitz H Robert HR Sternberg Paul W PW Ringstad Niels N

Proceedings of the National Academy of Sciences of the United States of America 20101220 1

CO(2) is both a critical regulator of animal physiology and an important sensory cue for many animals for host detection, food location, and mate finding. The free-living soil nematode Caenorhabditis elegans shows CO(2) avoidance behavior, which requires a pair of ciliated sensory neurons, the BAG neurons. Using in vivo calcium imaging, we show that CO(2) specifically activates the BAG neurons and that the CO(2)-sensing function of BAG neurons requires TAX-2/TAX-4 cyclic nucleotide-gated ion cha ...[more]

PMID: 21173231

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