Stereoselective effects of 4-hydroxynonenal in cultured mouse hepatocytes.
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ABSTRACT:
SUBMITTER: Dabrowski MJ
PROVIDER: S-EPMC3017229 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
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Stereoselective effects of 4-hydroxynonenal in cultured mouse hepatocytes.
Dabrowski Michael J MJ Zolnerciks Joseph K JK Balogh Larissa M LM Greene Robert J RJ Kavanagh Terrance J TJ Atkins William M WM
Chemical research in toxicology 20100928 10
4-Hydroxynonenal (HNE) is produced from arachidonic acid or linoleic acid during oxidative stress. Although HNE is formed in tissues as a racemate, enantiospecific HNE effects have not been widely documented, nor considered. Therefore, a panel of cellular responses was compared after treatment with (R)-HNE, (S)-HNE, or racemic HNE. The phosphorylation status of Jun kinase (JNK) or Akt increased 28-fold or 2-3-fold, respectively, after treatment with 100 μM (S)-HNE and racemic HNE compared to (R) ...[more]
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