Ontology highlight
ABSTRACT:
SUBMITTER: McDonald SM
PROVIDER: S-EPMC3017428 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
McDonald Seth M SM Close Devin D Xin Hua H Formosa Tim T Hill Christopher P CP
Molecular cell 20101125 5
Eukaryotic transcription and mRNA processing depend upon the coordinated interactions of many proteins, including Spn1 and Spt6, which are conserved across eukaryotes, are essential for viability, and associate with each other in some of their biologically important contexts. Here we report crystal structures of the Spn1 core alone and in complex with the binding determinant of Spt6. Mutating interface residues greatly diminishes binding in vitro and causes strong phenotypes in vivo, including a ...[more]