Ontology highlight
ABSTRACT:
SUBMITTER: Sytnikova YA
PROVIDER: S-EPMC3017548 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Sytnikova Yuliya A YA Kubarenko Andriy V AV Schäfer Andrea A Weber Alexander N R AN Niehrs Christof C
PloS one 20110107 1
<h4>Background</h4>The Gadd45 proteins play important roles in growth control, maintenance of genomic stability, DNA repair, and apoptosis. Recently, Gadd45 proteins have also been implicated in epigenetic gene regulation by promoting active DNA demethylation. Gadd45 proteins have sequence homology with the L7Ae/L30e/S12e RNA binding superfamily of ribosomal proteins, which raises the question if they may interact directly with nucleic acids.<h4>Principal findings</h4>Here we show that Gadd45a b ...[more]