Ontology highlight
ABSTRACT:
SUBMITTER: Furlan-Magaril M
PROVIDER: S-EPMC3017597 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Furlan-Magaril Mayra M Rebollar Eria E Guerrero Georgina G Fernández Almudena A Moltó Eduardo E González-Buendía Edgar E Cantero Marta M Montoliu Lluís L Recillas-Targa Félix F
Nucleic acids research 20100902 1
Genome organization into transcriptionally active domains denotes one of the first levels of gene expression regulation. Although the chromatin domain concept is generally accepted, only little is known on how domain organization impacts the regulation of differential gene expression. Insulators might hold answers to address this issue as they delimit and organize chromatin domains. We have previously identified a CTCF-dependent insulator with enhancer-blocking activity embedded in the 5' non-co ...[more]