Ontology highlight
ABSTRACT:
SUBMITTER: Taura M
PROVIDER: S-EPMC3017608 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Taura Manabu M Suico Mary Ann MA Fukuda Ryosuke R Koga Tomoaki T Shuto Tsuyoshi T Sato Takashi T Morino-Koga Saori S Okada Seiji S Kai Hirofumi H
Nucleic acids research 20100830 1
Myeloid elf-1-like factor (MEF) or Elf4 is an E-twenty-six (ETS)-related transcription factor with strong transcriptional activity that influences cellular senescence by affecting tumor suppressor p53. MEF downregulates p53 expression and inhibits p53-mediated cellular senescence by transcriptionally activating MDM2. However, whether p53 reciprocally opposes MEF remains unexplored. Here, we show that MEF is modulated by p53 in human cells and mice tissues. MEF expression and promoter activity we ...[more]