Platelet proteome changes associated with diabetes and during platelet storage for transfusion.
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ABSTRACT:
SUBMITTER: Springer DL
PROVIDER: S-EPMC3017716 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Platelet proteome changes associated with diabetes and during platelet storage for transfusion.
Springer David L DL Miller John H JH Spinelli Sherry L SL Pasa-Tolic Ljiljana L Purvine Samuel O SO Daly Donald S DS Zangar Richard C RC Jin Shuangshuang S Blumberg Neil N Francis Charles W CW Taubman Mark B MB Casey Ann E AE Wittlin Steven D SD Phipps Richard P RP
Journal of proteome research 20090501 5
Human platelets play a key role in hemostasis and thrombosis and have recently emerged as key regulators of inflammation. Platelets stored for transfusion produce pro-thrombotic and pro-inflammatory mediators implicated in adverse transfusion reactions. Correspondingly, these mediators are central players in pathological conditions including cardiovascular disease, the major cause of death in diabetics. In view of this, a mass spectrometry based proteomics study was performed on platelets collec ...[more]
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