Ontology highlight
ABSTRACT:
SUBMITTER: Kolodkin AN
PROVIDER: S-EPMC3018161 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Molecular systems biology 20101201
The topology of nuclear receptor (NR) signaling is captured in a systems biological graphical notation. This enables us to identify a number of 'design' aspects of the topology of these networks that might appear unnecessarily complex or even functionally paradoxical. In realistic kinetic models of increasing complexity, calculations show how these features correspond to potentially important design principles, e.g.: (i) cytosolic 'nuclear' receptor may shuttle signal molecules to the nucleus, ( ...[more]