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Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.

ABSTRACT: Troponin-mediated Ca²(+)-regulation governs the actin-activated myosin motor function which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the structure-function relationship of troponin T, one of the three protein subunits of the troponin complex. Molecular evolution, gene regulation, alternative RNA splicing, and posttranslational modifications of troponin T isoforms in skeletal and cardiac muscles are summarized with emphases on recent research progresses. The physiological and pathophysiological significances of the structural diversity and regulation of troponin T are discussed for impacts on striated muscle function and adaptation in health and diseases.

SUBMITTER: Wei B

PROVIDER: S-EPMC3018564 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.

Wei Bin B Jin J-P JP

Archives of biochemistry and biophysics 20101018 2

Troponin-mediated Ca²(+)-regulation governs the actin-activated myosin motor function which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the structure-function relationship of troponin T, one of the three protein subunits of the troponin complex. Molecular evolution, gene regulation, alternative RNA splicing, and posttranslational modifications of troponin T isoforms in skeletal and cardiac muscles are summarized with emphases on recent research progresses. T ...[more]

PMID: 20965144

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