Ontology highlight
ABSTRACT:
SUBMITTER: Jin LQ
PROVIDER: S-EPMC3018571 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Jin Li-Qing LQ Zhang Guixin G Pennicooke Brenton B Laramore Cindy C Selzer Michael E ME
Brain research 20101216
In mammals, there are three neurofilament (NF) subunits (NF-L, NF-M, and NF-H), but it was thought that only a single NF, NF180, exists in lamprey. However, NF180 lacked the ability to self-assemble, suggesting that like mammalian NFs, lamprey NFs are heteropolymers, and that additional NF subunits may exist. The present study provides evidence for the existence of a lamprey NF-L homolog (L-NFL). Genes encoding two new NF-M isoforms (NF132 and NF95) also have been isolated and characterized. Wit ...[more]