Ontology highlight
ABSTRACT:
SUBMITTER: Hoffstrom BG
PROVIDER: S-EPMC3018711 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Hoffstrom Benjamin G BG Kaplan Anna A Letso Reka R Schmid Ralf S RS Turmel Gregory J GJ Lo Donald C DC Stockwell Brent R BR
Nature chemical biology 20101031 12
A hallmark of many neurodegenerative diseases is accumulation of misfolded proteins within neurons, leading to cellular dysfunction and cell death. Although several mechanisms have been proposed to link protein misfolding to cellular toxicity, the connection remains enigmatic. Here, we report a cell death pathway involving protein disulfide isomerase (PDI), a protein chaperone that catalyzes isomerization, reduction and oxidation of disulfides. Through a small molecule screening approach, we dis ...[more]