Ontology highlight
ABSTRACT:
SUBMITTER: Painter JN
PROVIDER: S-EPMC3019124 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Painter Jodie N JN Anderson Carl A CA Nyholt Dale R DR Macgregor Stuart S Lin Jianghai J Lee Sang Hong SH Lambert Ann A Zhao Zhen Z ZZ Roseman Fenella F Guo Qun Q Gordon Scott D SD Wallace Leanne L Henders Anjali K AK Visscher Peter M PM Kraft Peter P Martin Nicholas G NG Morris Andrew P AP Treloar Susan A SA Kennedy Stephen H SH Missmer Stacey A SA Montgomery Grant W GW Zondervan Krina T KT
Nature genetics 20101212 1
Endometriosis is a common gynecological disease associated with pelvic pain and subfertility. We conducted a genome-wide association study (GWAS) in 3,194 individuals with surgically confirmed endometriosis (cases) and 7,060 controls from Australia and the UK. Polygenic predictive modeling showed significantly increased genetic loading among 1,364 cases with moderate to severe endometriosis. The strongest association signal was on 7p15.2 (rs12700667) for 'all' endometriosis (P = 2.6 × 10⁻⁷, odds ...[more]