Ontology highlight
ABSTRACT:
SUBMITTER: Brossier F
PROVIDER: S-EPMC3019671 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Brossier F F Veziris N N Truffot-Pernot C C Jarlier V V Sougakoff W W
Antimicrobial agents and chemotherapy 20101025 1
Ethionamide (ETH) needs to be activated by the mono-oxygenase EthA, which is regulated by EthR, in order to be active against Mycobacterium tuberculosis. The activated drug targets the enzyme InhA, which is involved in cell wall biosynthesis. Resistance to ETH has been reported to result from various mechanisms, including mutations altering EthA/EthR, InhA and its promoter, the NADH dehydrogenase encoded by ndh, and the MshA enzyme, involved in mycothiol biosynthesis. We searched for such mutati ...[more]