Ontology highlight
ABSTRACT:
SUBMITTER: Woo HH
PROVIDER: S-EPMC3019847 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Woo Ho-Hyung HH Yi Xiaofang X Lamb Tiffany T Menzl Ina I Baker Terri T Shapiro David J DJ Chambers Setsuko K SK
Molecular and cellular biology 20101025 1
cis-acting elements found in 3'-untranslated regions (UTRs) are regulatory signals determining mRNA stability and translational efficiency. By binding a novel non-AU-rich 69-nucleotide (nt) c-fms 3' UTR sequence, we previously identified HuR as a promoter of c-fms proto-oncogene mRNA. We now identify the 69-nt c-fms mRNA 3' UTR sequence as a cellular vigilin target through which vigilin inhibits the expression of c-fms mRNA and protein. Altering association of either vigilin or HuR with c-fms mR ...[more]