Ontology highlight
ABSTRACT:
SUBMITTER: Wallace SW
PROVIDER: S-EPMC3019857 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20101025 1
Rho GTPases regulate multiple signaling pathways to control a number of cellular processes during epithelial morphogenesis. To investigate the downstream pathways through which Rho regulates epithelial apical junction formation, we screened a small interfering RNA (siRNA) library targeting 28 known Rho target proteins in 16HBE human bronchial epithelial cells. This led to the identification of the serine-threonine kinase PRK2 (protein kinase C-related kinase 2, also called PKN2). Depletion of PR ...[more]