Ontology highlight
ABSTRACT:
SUBMITTER: Erdmann F
PROVIDER: S-EPMC3020109 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Erdmann Frank F Schäuble Nico N Lang Sven S Jung Martin M Honigmann Alf A Ahmad Mazen M Dudek Johanna J Benedix Julia J Harsman Anke A Kopp Annika A Helms Volkhard V Cavalié Adolfo A Wagner Richard R Zimmermann Richard R
The EMBO journal 20101123 1
In eukaryotes, protein transport into the endoplasmic reticulum (ER) is facilitated by a protein-conducting channel, the Sec61 complex. The presence of large, water-filled pores with uncontrolled ion permeability, as formed by Sec61 complexes in the ER membrane, would seriously interfere with the regulated release of calcium from the ER lumen into the cytosol, an essential mechanism for intracellular signalling. We identified a calmodulin (CaM)-binding motif in the cytosolic N-terminus of mammal ...[more]