Metalloprotease type III effectors that specifically cleave JNK and NF-?B.
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ABSTRACT:
SUBMITTER: Baruch K
PROVIDER: S-EPMC3020117 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Metalloprotease type III effectors that specifically cleave JNK and NF-κB.
Baruch Kobi K Gur-Arie Lihi L Nadler Chen C Koby Simi S Yerushalmi Gal G Ben-Neriah Yinon Y Yogev Orli O Shaulian Eitan E Guttman Chen C Zarivach Raz R Rosenshine Ilan I
The EMBO journal 20101126 1
Two major arms of the inflammatory response are the NF-κB and c-Jun N-terminal kinase (JNK) pathways. Here, we show that enteropathogenic Escherichia coli (EPEC) employs the type III secretion system to target these two signalling arms by injecting host cells with two effector proteins, NleC and NleD. We provide evidence that NleC and NleD are Zn-dependent endopeptidases that specifically clip and inactivate RelA (p65) and JNK, respectively, thus blocking NF-κB and AP-1 activation. We show that ...[more]
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