Ontology highlight
ABSTRACT:
SUBMITTER: Lipowsky G
PROVIDER: S-EPMC302028 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Lipowsky G G Bischoff F R FR Schwarzmaier P P Kraft R R Kostka S S Hartmann E E Kutay U U Görlich D D
The EMBO journal 20000801 16
Transport receptors of the importin beta superfamily account for many of the nuclear import and export events in eukaryotic cells. They mediate translocation through nuclear pore complexes, shuttle between nucleus and cytoplasm and co-operate with the RanGTPase system to regulate their interactions with cargo molecules in a compartment-specific manner. We used affinity chromatography on immobilized RanGTP to isolate further candidate nuclear transport receptors and thereby identified exportin 4 ...[more]