Ontology highlight
ABSTRACT:
SUBMITTER: Devaney JM
PROVIDER: S-EPMC3020305 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Devaney Joseph M JM Gordish-Dressman Heather H Harmon Brennan T BT Bradbury Margaret K MK Devaney Stephanie A SA Harris Tamara B TB Thompson Paul D PD Clarkson Priscilla M PM Price Thomas B TB Angelopoulos Theodore J TJ Gordon Paul M PM Moyna Niall M NM Pesca Linda S LS VIsich Paul S PS Zoeller Robert F RF Seip Richard L RL Seo Jinwook J Kim Bo Hyoung BH Tosi Laura L LL Garcia Melissa M Li Rongling R Zmuda Joseph M J Delmonico Matthew J MJ Lindsay Robert S RS Howard Barbara V BV Kraus William E WE Hoffman Eric P EP
Human genetics 20110201 2
Converging lines of evidence suggest that AKT1 is a major mediator of the responses to insulin,insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. We hypothesized that AKT1 variants may play a role in the endophenotypes that makeup metabolic syndrome. We studied a 12-kb region including the first exon of the AKT1 gene for association with metabolic syndrome-related phenotypes in four study populations [FAMUSS ...[more]