Ontology highlight
ABSTRACT:
SUBMITTER: Dessen A
PROVIDER: S-EPMC302032 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Dessen A A Volchkov V V Dolnik O O Klenk H D HD Weissenhorn W W
The EMBO journal 20000801 16
Ebola virus maturation occurs at the plasma membrane of infected cells and involves the clustering of the viral matrix protein VP40 at the assembly site as well as its interaction with the lipid bilayer. Here we report the X-ray crystal structure of VP40 from Ebola virus at 2.0 A resolution. The crystal structure reveals that Ebola virus VP40 is topologically distinct from all other known viral matrix proteins, consisting of two domains with unique folds, connected by a flexible linker. The C-te ...[more]