Ontology highlight
ABSTRACT:
SUBMITTER: Jelenska J
PROVIDER: S-EPMC30206 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Jelenska J J Crawford M J MJ Harb O S OS Zuther E E Haselkorn R R Roos D S DS Gornicki P P
Proceedings of the National Academy of Sciences of the United States of America 20010213 5
Apicomplexan parasites such as Toxoplasma gondii contain a primitive plastid, the apicoplast, whose genome consists of a 35-kb circular DNA related to the plastid DNA of plants. Plants synthesize fatty acids in their plastids. The first committed step in fatty acid synthesis is catalyzed by acetyl-CoA carboxylase (ACC). This enzyme is encoded in the nucleus, synthesized in the cytosol, and transported into the plastid. In the present work, two genes encoding ACC from T. gondii were cloned and th ...[more]