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Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown.

ABSTRACT: The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells.

SUBMITTER: Pradhan AD

PROVIDER: S-EPMC3021499 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown.

Pradhan A D AD Case A M AM Farrer R G RG Tsai S Y SY Cheatwood J L JL Martin J L JL Kartje G L GL

Developmental neuroscience 20101013 4

The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenot ...[more]

PMID: 20938157

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