Targeted regeneration of bone in the osteoporotic human femur.
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ABSTRACT:
SUBMITTER: Poole KE
PROVIDER: S-EPMC3021547 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Targeted regeneration of bone in the osteoporotic human femur.
Poole Kenneth E S KE Treece Graham M GM Ridgway Gerard R GR Mayhew Paul M PM Borggrefe Jan J Gee Andrew H AH
PloS one 20110114 1
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhan ...[more]
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