MiR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3022257 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
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miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.
Zhang Lingbo L Flygare Johan J Wong Piu P Lim Bing B Lodish Harvey F HF
Genes & development 20101231 2
Using RNA-seq technology, we found that the majority of microRNAs (miRNAs) present in CFU-E erythroid progenitors are down-regulated during terminal erythroid differentiation. Of the developmentally down-regulated miRNAs, ectopic overexpression of miR-191 blocks erythroid enucleation but has minor effects on proliferation and differentiation. We identified two erythroid-enriched and developmentally up-regulated genes, Riok3 and Mxi1, as direct targets of miR-191. Knockdown of either Riok3 or Mxi ...[more]
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