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Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder.

ABSTRACT: OBJECTIVE:Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with a strong genetic component. Brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in ADHD development. We aimed to explore the relationships between ADHD and BDNF gene polymorphism. METHODS:We conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test on 151 trios, and compared the results of a continuous performance test (CPT) according to the genotype of the three single nucleotide polymorphisms (rs11030101, rs6265, rs16917204) in the BDNF gene. RESULTS:In the case-control analysis, the AA genotype of the BDNF rs11030101 polymorphism was significantly associated with ADHD only in girls (p=0.024, odds ratio=3.00). The T-G-G haplotype was significantly less frequent (p=0.005) and A-G-G was more frequent (p=0.048) in girls with ADHD than in control girls (global p=0.027). A multivariate analysis of variance for commission errors on the CPT showed a significant main effect for the rs11030101 genotype (p=0.026) and an interaction effect of the rs11030101 genotype and gender (p=0.032) in ADHD probands. CONCLUSION:These results provide preliminary evidence for a gender-specific association between BDNF and ADHD in the Korean population.

SUBMITTER: Cho SC

PROVIDER: S-EPMC3022316 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder.

Cho Soo-Churl SC Kim Hyo-Won HW Kim Boong-Nyun BN Kim Jae-Won JW Shin Min-Sup MS Chung Seockhoon S Cho Dae-Yeon DY Jung Sun-Woo SW Yoo Hee Jeong HJ Chung In-Won IW Chung Un-Sun US Son Jung-Woo JW

Psychiatry investigation 20101123 4

<h4>Objective</h4>Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder with a strong genetic component. Brain-derived neurotrophic factor (BDNF), which participates in the differentiation and survival of dopaminergic and noradrenergic neurons, could play a role in ADHD development. We aimed to explore the relationships between ADHD and BDNF gene polymorphism.<h4>Methods</h4>We conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a ...[more]

PMID: 21253413

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Project description:IntroductionAttention-deficit hyperactive disorder (ADHD) is the most common neurodevelopmental disorder in children. Diagnosis is currently based on behavioral criteria, but magnetic resonance imaging (MRI) of the brain is increasingly used in ADHD research. To date however, MRI studies have provided mixed results in ADHD patients, particularly with respect to the laterality of findings.MethodsWe studied 849 children and adolescents (ages 6-21?y.o.) diagnosed with ADHD (n?=?341) and age-matched typically developing (TD) controls with structural brain MRI. We calculated volumetric measures from 34 cortical and 14 non-cortical brain regions per hemisphere, and detailed shape morphometry of subcortical nuclei. Diffusion tensor imaging (DTI) data were collected for a subset of 104 subjects; from these, we calculated mean diffusivity and fractional anisotropy of white matter tracts. Group comparisons were made for within-hemisphere (right/left) and between hemisphere asymmetry indices (AI) for each measure.ResultsDTI mean diffusivity AI group differences were significant in cingulum, inferior and superior longitudinal fasciculus, and cortico-spinal tracts (p?<?0.001) with the effect of stimulant treatment tending to reduce these patterns of asymmetry differences. Gray matter volumes were more asymmetric in medication free ADHD individuals compared to TD in twelve cortical regions and two non-cortical volumes studied (p?<?0.05). Morphometric analyses revealed that caudate, hippocampus, thalamus, and amygdala were more asymmetric (p?<?0.0001) in ADHD individuals compared to TD, and that asymmetry differences were more significant than lateralized comparisons.ConclusionsBrain asymmetry measures allow each individual to serve as their own control, diminishing variability between individuals and when pooling data across sites. Asymmetry group differences were more significant than lateralized comparisons between ADHD and TD subjects across morphometric, volumetric, and DTI comparisons.

Dataset Information

Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder.

Publications

Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder.

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