DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma.

ABSTRACT:

Background

Although much is known about molecular and chromosomal characteristics that distinguish glioma histological subtypes, DNA methylation patterns of gliomas and their association with other tumor features such as mutation of isocitrate dehydrogenase (IDH) genes have only recently begun to be investigated.

Methods

DNA methylation of glioblastomas, astrocytomas, oligodendrogliomas, oligoastrocytomas, ependymomas, and pilocytic astrocytomas (n = 131) from the Brain Tumor Research Center at the University of California San Francisco, as well as nontumor brain tissues (n = 7), was assessed with the Illumina GoldenGate methylation array. Methylation data were subjected to recursively partitioned mixture modeling (RPMM) to derive methylation classes. Differential DNA methyl

SUBMITTER: Christensen BC 

PROVIDER: S-EPMC3022619 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature