Ontology highlight
ABSTRACT:
SUBMITTER: Stone RM
PROVIDER: S-EPMC3023007 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Stone Richard M RM Moser Barry B Sanford Ben B Schulman Philip P Kolitz Jonathan E JE Allen Steven S Stock Wendy W Galinsky Ilene I Vij Ravi R Marcucci Guido G Hurd David D Larson Richard A RA
Leukemia research 20100804 3
Gemtuzumab ozogamicin (GO), an anti-CD33 immunoconjugate, was combined with high dose cytarabine (HiDAC; cytarabine 3g/m(2) over 3h daily for 5 days) for adults with relapsed or refractory AML. HiDAC plus GO 9mg/m(2) on day 7 and 4.5mg/m(2) on day 14 was not tolerated, but HiDAC followed by GO 9mg/m(2) on day 7 was safe: 12/37 (32%) patients with relapsed AML achieved complete remission. Median overall survival was 8.9 months. No grade 4 hepatic veno-occlusive disease was observed. This regimen ...[more]