Where does the alignment score distribution shape come from?
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ABSTRACT:
SUBMITTER: Ortet P
PROVIDER: S-EPMC3023300 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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Where does the alignment score distribution shape come from?
Ortet Philippe P Bastien Olivier O
Evolutionary bioinformatics online 20101212
Alignment algorithms are powerful tools for searching for homologous proteins in databases, providing a score for each sequence present in the database. It has been well known for 20 years that the shape of the score distribution looks like an extreme value distribution. The extremely large number of times biologists face this class of distributions raises the question of the evolutionary origin of this probability law.WE INVESTIGATED THE POSSIBILITY OF DERIVING THE MAIN PROPERTIES OF SEQUENCE A ...[more]
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