Ontology highlight
ABSTRACT:
SUBMITTER: Csepeggi C
PROVIDER: S-EPMC3023505 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Csepeggi Chad C Jiang Min M Kojima Fumiaki F Crofford Leslie J LJ Frolov Andrey A
The Journal of biological chemistry 20101117 3
A growing body of evidence points toward activated fibroblasts, also known as myofibroblasts, as one of the leading mediators in several major human pathologies including proliferative fibrotic disorders, invasive tumor growth, rheumatoid arthritis, and atherosclerosis. Niemann-Pick Type C2 (NPC2) protein has been recently identified as a product of the second gene in NPC disease. It encodes ubiquitous, highly conserved, secretory protein with the poorly defined function. Here we show that NPC2 ...[more]