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Hepatitis C virus genotype 3a with phylogenetically distinct origin is circulating in Pakistan.


ABSTRACT: BACKGROUND:Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan. FINDINGS:The present study reports the first full sequence of HCV 3a isolate PK-1 from Pakistan. This nucleotide sequence was compared with six other HCV genotype 3a full length sequences from different regions of the world by using statistical methods of phylogenetic analysis. CONCLUSION:The nucleotide difference of these seven sequences shows that HCV genotype 3a of phylogenetically distinct origin is circulating in Pakistan.

SUBMITTER: Rehman IU 

PROVIDER: S-EPMC3023652 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Hepatitis C virus genotype 3a with phylogenetically distinct origin is circulating in Pakistan.

Rehman Irshad-Ur IU   Idrees Muhammad M   Ali Muhammad M   Ali Liaqat L   Butt Sadia S   Hussain Abrar A   Akbar Haji H   Afzal Samia S  

Genetic vaccines and therapy 20110106 1


<h4>Background</h4>Hepatitis C virus (HCV) is one of the leading causes of viral hepatitis worldwide and its genotype 3a is predominant in vast areas of Pakistan.<h4>Findings</h4>The present study reports the first full sequence of HCV 3a isolate PK-1 from Pakistan. This nucleotide sequence was compared with six other HCV genotype 3a full length sequences from different regions of the world by using statistical methods of phylogenetic analysis.<h4>Conclusion</h4>The nucleotide difference of thes  ...[more]

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