Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells.
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ABSTRACT:
SUBMITTER: Satelli A
PROVIDER: S-EPMC3023883 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
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Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells.
Satelli Arun A Rao U Subrahmanyeswara US
Cancer letters 20101130 1
Galectin-1 (gal-1) is an important molecule secreted by many tumors, which induces apoptosis in activated T-cells and promotes tumor angiogenesis, both of which phenomena facilitate successful establishment of tumor in the body. However, little is known about the function of intracellular gal-1 or its transcriptional regulation in colorectal cancer (CRC). Here, we demonstrate that gal-1 expression is epigenetically regulated in CRC through promoter hypermethylation. Intracellular gal-1 induces c ...[more]
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