Ontology highlight
ABSTRACT:
SUBMITTER: Hwang YS
PROVIDER: S-EPMC3023993 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Hwang Yoo-Seok YS Luo Ting T Xu Yanhua Y Sargent Thomas D TD
Developmental dynamics : an official publication of the American Association of Anatomists 20091001 10
Myosin-X (MyoX) belongs to a large family of unconventional, nonmuscle, actin-dependent motor proteins. We show that MyoX is predominantly expressed in cranial neural crest (CNC) cells in embryos of Xenopus laevis and is required for head and jaw cartilage development. Knockdown of MyoX expression using antisense morpholino oligonucleotides resulted in retarded migration of CNC cells into the pharyngeal arches, leading to subsequent hypoplasia of cartilage and inhibited outgrowth of the CNC-deri ...[more]