Ontology highlight
ABSTRACT:
SUBMITTER: Vossel KA
PROVIDER: S-EPMC3024010 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Vossel Keith A KA Zhang Kai K Brodbeck Jens J Daub Aaron C AC Sharma Punita P Finkbeiner Steven S Cui Bianxiao B Mucke Lennart L
Science (New York, N.Y.) 20100909 6001
Amyloid-β (Aβ) peptides, derived from the amyloid precursor protein, and the microtubule-associated protein tau are key pathogenic factors in Alzheimer's disease (AD). How exactly they impair cognitive functions is unknown. We assessed the effects of Aβ and tau on axonal transport of mitochondria and the neurotrophin receptor TrkA, cargoes that are critical for neuronal function and survival and whose distributions are altered in AD. Aβ oligomers rapidly inhibited axonal transport of these cargo ...[more]