Ontology highlight
ABSTRACT:
SUBMITTER: Sun SG
PROVIDER: S-EPMC3024123 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
EMBO reports 20101126 1
MicroRNAs are phenotypic regulators of vascular smooth muscle cells (VSMCs). In this paper, we demonstrate that miR-146a targets the Krüppel-like factor 4 (KLF4) 3'-untranslated region and has an important role in promoting VSMC proliferation in vitro and vascular neointimal hyperplasia in vivo. Silencing of miR-146a in VSMCs increases KLF4 expression, whereas overexpression of miR-146a decreases KLF4 levels. Furthermore, we demonstrate that KLF4 competes with Krüppel-like factor 5 (KLF5) to bin ...[more]