Ontology highlight
ABSTRACT:
SUBMITTER: Langelaan DN
PROVIDER: S-EPMC3024292 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Langelaan David N DN Rainey Jan K JK
Biochemistry and cell biology = Biochimie et biologie cellulaire 20100401 2
The membrane catalysis hypothesis states that a peptide ligand activates its target receptor after an initial interaction with the surrounding membrane. Upon membrane binding and interaction, the ligand is structured such that receptor binding and activation is encouraged. As evidence for this hypothesis, there are numerous studies concerning the conformation that peptides adopt in membrane mimetic environments. This mini-review analyzes the features of ligand peptides with an available high-res ...[more]