Joint genetic analysis of gene expression data with inferred cellular phenotypes.
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ABSTRACT:
SUBMITTER: Parts L
PROVIDER: S-EPMC3024309 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
Joint genetic analysis of gene expression data with inferred cellular phenotypes.
Parts Leopold L Stegle Oliver O Winn John J Durbin Richard R
PLoS genetics 20110120 1
Even within a defined cell type, the expression level of a gene differs in individual samples. The effects of genotype, measured factors such as environmental conditions, and their interactions have been explored in recent studies. Methods have also been developed to identify unmeasured intermediate factors that coherently influence transcript levels of multiple genes. Here, we show how to bring these two approaches together and analyse genetic effects in the context of inferred determinants of ...[more]
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