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A structural and functional ground plan for neurons in the hindbrain of zebrafish.

ABSTRACT: The vertebrate hindbrain contains various sensory-motor networks controlling movements of the eyes, jaw, head, and body. Here we show that stripes of neurons with shared neurotransmitter phenotype that extend throughout the hindbrain of young zebrafish reflect a broad underlying structural and functional patterning. The neurotransmitter stripes contain cell types with shared gross morphologies and transcription factor markers. Neurons within a stripe are stacked systematically by extent and location of axonal projections, input resistance, and age, and are recruited along the axis of the stripe during behavior. The implication of this pattern is that the many networks in hindbrain are constructed from a series of neuronal components organized into stripes that are ordered from top to bottom according to a neuron's age, structural and functional properties, and behavioral roles. This simple organization probably forms a foundation for the construction of the networks underlying the many behaviors produced by the hindbrain.

SUBMITTER: Kinkhabwala A

PROVIDER: S-EPMC3024665 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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A structural and functional ground plan for neurons in the hindbrain of zebrafish.

Kinkhabwala Amina A Riley Michael M Koyama Minoru M Monen Joost J Satou Chie C Kimura Yukiko Y Higashijima Shin-Ichi S Fetcho Joseph J

Proceedings of the National Academy of Sciences of the United States of America 20110103 3

The vertebrate hindbrain contains various sensory-motor networks controlling movements of the eyes, jaw, head, and body. Here we show that stripes of neurons with shared neurotransmitter phenotype that extend throughout the hindbrain of young zebrafish reflect a broad underlying structural and functional patterning. The neurotransmitter stripes contain cell types with shared gross morphologies and transcription factor markers. Neurons within a stripe are stacked systematically by extent and loca ...[more]

PMID: 21199947

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Dataset Information

A structural and functional ground plan for neurons in the hindbrain of zebrafish.

Publications

A structural and functional ground plan for neurons in the hindbrain of zebrafish.

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