Ontology highlight
ABSTRACT:
SUBMITTER: Leduc MS
PROVIDER: S-EPMC3025299 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Leduc Magalie S MS Hageman Rachael S RS Meng Qingying Q Verdugo Ricardo A RA Tsaih Shirng-Wern SW Churchill Gary A GA Paigen Beverly B Yuan Rong R
Aging cell 20101001 5
The IGF-1 signaling pathway plays an important role in regulating longevity. To identify the genetic loci and genes that regulate plasma IGF-1 levels, we intercrossed MRL/MpJ and SM/J, inbred mouse strains that differ in IGF-1 levels. Quantitative trait loci (QTL) analysis of IGF-1 levels of these F2 mice detected four QTL on chromosomes (Chrs) 9 (48 Mb), 10 (86 Mb), 15 (18 Mb), and 17 (85 Mb). Haplotype association mapping of IGF-1 levels in 28 domesticated inbred strains identified three sugge ...[more]