Ontology highlight
ABSTRACT:
SUBMITTER: Kurihara N
PROVIDER: S-EPMC3025409 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Kurihara Noriyoshi N Hiruma Yuko Y Yamana Kei K Michou Laëtitia L Rousseau Côme C Morissette Jean J Galson Deborah L DL Teramachi Jumpei J Zhou Hua H Dempster David W DW Windle Jolene J JJ Brown Jacques P JP Roodman G David GD
Cell metabolism 20110101 1
Paget's disease (PD) is characterized by abnormal osteoclasts (OCL) that secrete high IL-6 levels and induce exuberant bone formation. Because measles virus nucleocapsid gene (MVNP) and the p62(P392L) mutation are implicated in PD, marrows from 12 PD patients harboring p62(P392L) and eight normals were tested for MVNP expression and pagetic OCL formation. Eight out of twelve patients expressed MVNP and formed pagetic OCL in vitro, which were inhibited by antisense-MVNP. Four out of twelve patien ...[more]