Ontology highlight
ABSTRACT:
SUBMITTER: Tu Z
PROVIDER: S-EPMC3025445 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Tu Zhigang Z Young Albert A Murphy Christopher C Liang Jun F JF
Journal of peptide science : an official publication of the European Peptide Society 20091101 11
Many bioactive peptides are featured by their unique amino acid compositions such as argine/lysine-rich peptides. However, histidine-rich bioactive peptides are hardly found. In this study, histidine-containing peptides were constructed by selectively replacing the corresponded lysine residues in a lytic peptide LL-1 with histidines. Interestingly, all resulting peptides demonstrated pH-dependent activities. The cell lysis activities of these peptides could be increased up to four times as the s ...[more]