MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.
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ABSTRACT:
SUBMITTER: Germain M
PROVIDER: S-EPMC3025469 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
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MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.
Germain Marc M Nguyen Angela P AP Le Grand J Nicole JN Arbour Nicole N Vanderluit Jacqueline L JL Park David S DS Opferman Joseph T JT Slack Ruth S RS
The EMBO journal 20101207 2
Apoptosis has an important role during development to regulate cell number. In differentiated cells, however, activation of autophagy has a critical role by enabling cells to remain functional following stress. In this study, we show that the antiapoptotic BCL-2 homologue MCL-1 has a key role in controlling both processes in a developmentally regulated manner. Specifically, MCL-1 degradation is an early event not only following induction of apoptosis, but also under nutrient deprivation conditio ...[more]
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