Ontology highlight
ABSTRACT:
SUBMITTER: Cekic M
PROVIDER: S-EPMC3025702 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Cekic Milos M Sayeed Iqbal I Stein Donald G DG
Frontiers in neuroendocrinology 20090424 2
More than two decades of pre-clinical research and two recent clinical trials have shown that progesterone (PROG) and its metabolites exert beneficial effects after traumatic brain injury (TBI) through a number of metabolic and physiological pathways that can reduce damage in many different tissues and organ systems. Emerging data on 1,25-dihydroxyvitamin D(3) (VDH), itself a steroid hormone, have begun to provide evidence that, like PROG, it too is neuroprotective, although some of its actions ...[more]