Ontology highlight
ABSTRACT:
SUBMITTER: Zender L
PROVIDER: S-EPMC3026384 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Cell 20060601 7
The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through genomic approaches alone. Herein we describe a mouse model of liver cancer initiated from progenitor cells harboring defined cancer-predisposing lesions. Genome-wide analyses of tumors in this mouse model and in human hepatocellular carcinomas revealed a recurrent amplification at mouse chromosome 9qA1, the syntenic region of human chromosome 11q22. Gene-expression analyses ...[more]