Ontology highlight
ABSTRACT:
SUBMITTER: Edmonds JW
PROVIDER: S-EPMC3026445 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Edmonds Johnathan W JW Prasain Jeevan K JK Dorand Dixon D Yang Youfeng Y Hoang Hieu D HD Vibbert Jack J Kubagawa Homare M HM Miller Michael A MA
Developmental cell 20101201 6
Abnormalities in insulin/IGF-1 signaling are associated with infertility, but the molecular mechanisms are not well understood. Here we use liquid chromatography with electrospray ionization tandem mass spectrometry to show that the C. elegans insulin/FOXO pathway regulates the metabolism of locally acting lipid hormones called prostaglandins. C. elegans prostaglandins are synthesized without prostaglandin G/H synthase homologs, the targets of nonsteroidal anti-inflammatory drugs. Our results su ...[more]