Ontology highlight
ABSTRACT:
SUBMITTER: Hoover BR
PROVIDER: S-EPMC3026458 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Neuron 20101201 6
The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related deficits develop not from the loss of synapses or neurons, but rather as a result of synaptic abnormalities caused by the accumulation of hyperphosphorylated tau within intact dendritic ...[more]