?-Arrestin1 mediates the endocytosis and functions of macrophage migration inhibitory factor.
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ABSTRACT:
SUBMITTER: Xie L
PROVIDER: S-EPMC3026819 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Publications
β-Arrestin1 mediates the endocytosis and functions of macrophage migration inhibitory factor.
Xie Lishi L Qiao Xiaohang X Wu Yanfang Y Tang Jie J
PloS one 20110125 1
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, regulating inflammatory and immune responses. MIF binds to cell surface receptor CD74, resulting in both rapid and sustained ERK activation. It was reported that MIF-induced rapid ERK activation requires its co-receptor CD44. But the exact mechanism underlying sustained ERK activation is not well understood. In the current study, we described a detailed mechanism of MIF mediated sustained ERK activation. We found that β-arre ...[more]
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