Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC3027149 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Kim Hyeongjun H Hsin Jen J Liu Yanxin Y Selvin Paul R PR Schulten Klaus K
Structure (London, England : 1993) 20101101 11
The unconventional motor protein, myosin VI, is known to dimerize upon cargo binding to its C-terminal end. It has been shown that one of its tail domains, called the medial tail domain, is a dimerization region. The domain contains an unusual pattern of alternating charged residues and a few hydrophobic residues. To reveal the unknown dimerization mechanism of the medial tail domain, we employed molecular dynamics and single-molecule experimental techniques. Both techniques suggest that the for ...[more]