Ontology highlight
ABSTRACT:
SUBMITTER: Gleichmann M
PROVIDER: S-EPMC3027841 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Gleichmann Marc M Zhang Yongqing Y Wood William H WH Becker Kevin G KG Mughal Mohamed R MR Pazin Michael J MJ van Praag Henriette H Kobilo Tali T Zonderman Alan B AB Troncoso Juan C JC Markesbery William R WR Mattson Mark P MP
Neurobiology of aging 20101013 1
Activity-dependent modulation of neuronal gene expression promotes neuronal survival and plasticity, and neuronal network activity is perturbed in aging and Alzheimer's disease (AD). Here we show that cerebral cortical neurons respond to chronic suppression of excitability by downregulating the expression of genes and their encoded proteins involved in inhibitory transmission (GABAergic and somatostatin) and Ca(2+) signaling; alterations in pathways involved in lipid metabolism and energy manage ...[more]